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Article

Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30,K185Q] in the heart.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2007

Flagg Thomas P, Patton Brian, Masia Ricard, Mansfield Carrie, Lopatin Anatoli N, Yamada Kathryn A, Nichols Colin G

Abstract excerpt

Sarcolemmal ATP-sensitive potassium (K(ATP)) channels are activated after pathological depletion of intracellular ATP, unlike their pancreatic beta-cell counterparts, which dynamically regulate membrane excitability in response to changes in blood glucose. We recently engineered a series of transgenic (TG) mice overexpressing an ATP-insensitive inward rectifying K(+) channel protein (Kir)6.2 mutant...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multidrug Resistance-Associated Proteins

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Share to Potassium Channels, Inwardly Rectifying

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Identifiers

PMID: 17449558
DOI: 10.1152/ajpheart.00011.2007

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