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Article

Structural damage to meiotic chromosomes impairs DNA recombination and checkpoint control in mammalian oocytes.

The Journal of cell biology - 22 May 2006

Wang Hong, Höög Christer

Abstract excerpt

Meiosis in human oocytes is a highly error-prone process with profound effects on germ cell and embryo development. The synaptonemal complex protein 3 (SYCP3) transiently supports the structural organization of the meiotic chromosome axis. Offspring derived from murine Sycp3(-)(/)(-) females die in utero as a result of aneuploidy. We studied the nature of the proximal chromosomal defects that give rise to...

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Identifiers

PMID: 16717125
DOI: 10.1083/jcb.200512077
PMCID: PMC2063859

Genes

SYCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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