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Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.

PLoS genetics - 1 Sept 2025

Olaya Iván, Yilmaz Ilara N, Nour-Kasally Naima, Charboneau Ross E, Draper Bruce W, Burgess Sean M

Abstract excerpt

The synaptonemal complex (SC) is a meiosis-specific structure that aligns homologous chromosomes and promotes the repair of meiotic DNA double-strand breaks (DSBs). To investigate how defects in SC formation affect gametogenesis in zebrafish, we analyzed mutations in two genes encoding core SC components: syce2 and sycp1. In syce2 mutants, chromosomes exhibit partial synapsis, primarily at sub-telomeric regions,...

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Chromosome Pairing
DNA Breaks, Double-Stranded
Meiosis
Reproduction
Spermatocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Synaptonemal Complex

Zebrafish Proteins

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PMID: 40911633
DOI: 10.1371/journal.pgen.1011656
PMCID: PMC12425308

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Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.PMID 40911633Read ↗

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