Article
Synapsis-defective mutants reveal a correlation between chromosome conformation and the mode of double-strand break repair during Caenorhabditis elegans meiosis.
Genetics - 1 Aug 2007
Smolikov Sarit, Eizinger Andreas, Hurlburt Allison, Rogers Eric, Villeneuve Anne M, Colaiácovo Mónica P
Abstract excerpt
SYP-3 is a new structural component of the synaptonemal complex (SC) required for the regulation of chromosome synapsis. Both chromosome morphogenesis and nuclear organization are altered throughout the germlines of syp-3 mutants. Here, our analysis of syp-3 mutants provides insights into the relationship between chromosome conformation and the repair of meiotic double-strand breaks (DSBs). Although crossover...
Topics
- Animals
- Caenorhabditis elegans
- Chromosome Pairing
- Crossing Over, Genetic
- DNA Breaks, Double-Stranded
- DNA Repair
- Female
- Genes, Helminth
- Male
- Meiosis
- Mutation