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Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis

14 Dec 2021

Abstract excerpt

Aneuploidy is frequently observed in oocytes and early embryos, begging the question of how genome integrity is monitored and preserved during this crucial period. SMC3 is a subunit of the cohesin complex that supports genome integrity, but its role in maintaining the genome during this window of mammalian development is unknown. We discovered that, although depletion of Smc3 following meiotic S phase in mouse...

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PMID: 34935904
DOI: 10.1242/dev.199800

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