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Article

Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3.

Science (New York, N.Y.) - 10 May 2002

Yuan Li, Liu Jian-Guo, Hoja Mary-Rose, Wilbertz Johannes, Nordqvist Katarina, Höög Christer

Abstract excerpt

Aneuploidy (trisomy or monosomy) is the leading genetic cause of pregnancy loss in humans and results from errors in meiotic chromosome segregation. Here, we show that the absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation. The abnormal oocyte karyotype is inherited by embryos, which die in utero at an early stage of...

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Identifiers

PMID: 12004129
DOI: 10.1126/science.1070594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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