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Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors

26 Nov 2017

Abstract excerpt

BACKGROUND: Meiotic chromosome segregation in human oocytes is notoriously error-prone, especially with ageing. Such errors markedly reduce the reproductive chances of increasing numbers of women embarking on pregnancy later in life. However, understanding the basis for these errors is hampered by limited access to human oocytes. OBJECTIVE AND RATIONALE: Important new discoveries have arisen from molecular...

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PMID: 29244163
DOI: 10.1093/humupd/dmx035

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