Article

Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombination

2019-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Eukaryotic organisms have evolved mechanisms to prevent the accumulation of cells bearing genetic aberrations. This is especially crucial for the germline, because fecundity, and fitness of progeny would be adversely affected by an excessively high mutational incidence. The process of meiosis poses unique problems for mutation avoidance, due to the requirement for SPO11-induced programmed double...

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Literature Corpus work: 1cedb55f-8927-5d39-9334-4a77cc2835b8
DOI: 10.1101/768150

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