Article

Zebrafish lack a strong meiotic checkpoint response to defects in chromosome synapsis

2025-03-19

Abstract excerpt

The synaptonemal complex (SC) is a meiosis-specific structure that aligns homologous chromosomes and facilitates the repair of meiotic DNA double-strand breaks (DSBs). Defects in SC assembly or unrepaired DSBs trigger a prophase I checkpoint to prevent the formation of aneuploid gametes. The strength of these checkpoints varies among species and between sexes. Whether zebrafish ( Danio rerio ) have prophase I sur...

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Literature Corpus work: 8c8ea275-a160-5b65-9a0d-e6efcef491f9
DOI: 10.1101/2025.03.18.644038

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