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DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

2 Nov 2015

Abstract excerpt

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged embryos. Here we show that DNA damage activates a pathway involving the spindle assembly checkpoint (SAC) in response to chemically induced double strand breaks, UVB and ionizing radiation. DNA damage can occur either...

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PMID: 26522232
DOI: 10.1038/ncomms9553

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