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Article

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.

Molecular cell - 21 Sept 2017

Rinaldi Vera D, Bolcun-Filas Ewelina, Kogo Hiroshi, Kurahashi Hiroki, Schimenti John C

Abstract excerpt

Pairing and synapsis of homologous chromosomes during meiosis is crucial for producing genetically normal gametes and is dependent upon repair of SPO11-induced double-strand breaks (DSBs) by homologous recombination. To prevent transmission of genetic defects, diverse organisms have evolved mechanisms to eliminate meiocytes containing unrepaired DSBs or unsynapsed chromosomes. Here we show that the CHK2...

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Share to ATPases Associated with Diverse Cellular Activities
Share to Checkpoint Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Endodeoxyribonucleases

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Source

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Identifiers

PMID: 28844861
DOI: 10.1016/j.molcel.2017.07.027
PMCID: PMC5621520

Genes

SPO11
CHEK2
HORMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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