Article
The PTPN22 1858T variant is not associated with primary biliary cirrhosis.
Tissue antigens - 1 May 2006
Milkiewicz P, Pache I, Buwaneswaran H, Liu X, Coltescu C, Heathcote E J, Siminovitch K A
Abstract excerpt
The minor allele of a single nucleotide polymorphism (SNP) in the PTPN22 gene (1858T) encoding the Lyp-tyrosine phosphatase has been recently associated with multiple autoimmune disorders, raising the possibility that this variant may also represent a risk allele for primary biliary cirrhosis (PBC). We therefore investigated the possible association of the PTPN22(1858T) variant with PBC in a Canadian population....
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