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Article

A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.

Tissue antigens - 1 Oct 2005

Prescott N J, Fisher S A, Onnie C, Pattni R, Steer S, Sanderson J, Forbes A, Lewis C M, Mathew C G

Abstract excerpt

A single-nucleotide polymorphism (C1858T) causing an amino acid substitution (R620W) in the lymphoid protein tyrosine phosphatase gene PTPN22 has been implicated in type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, juvenile idiopathic arthritis and Hashimoto's thyroiditis, thus revealing a general role for this gene in autoimmune disease. We investigated the association of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16185328
DOI: 10.1111/j.1399-0039.2005.00494.x

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.PMID 16185328Read ↗

Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.Semantic proximity Read ↗

The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease.Semantic proximity Read ↗

A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.Semantic proximity Read ↗

Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.Semantic proximity Read ↗

PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.Semantic proximity Read ↗

Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.Semantic proximity Read ↗

Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.Semantic proximity Read ↗

Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.Semantic proximity Read ↗

Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.Semantic proximity Read ↗

The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.Semantic proximity Read ↗

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.Semantic proximity Read ↗

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