Article
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Arthritis and rheumatism - 1 Jul 2005
van Oene Mark, Wintle Richard F, Liu Xiangdong, Yazdanpanah Mehrdad, Gu Xiangjun, Newman Bill, Kwan Albert, Johnson Benjamin, Owen Julie, Greer Wenda, Mosher Dianne, Maksymowych Walter, Keystone Ed, Rubin Laurence A, Amos Christopher I, Siminovitch Katherine A
Abstract excerpt
OBJECTIVE: A single-nucleotide polymorphism in the PTPN22 gene encoding the lymphoid protein tyrosine phosphatase (Lyp) has recently been identified as a functional variant associated with susceptibility to rheumatoid arthritis (RA), type 1 diabetes, and systemic lupus erythematosus. To determine whether association of this variant (PTPN22 1858T) with RA is reproducible and is also observed in another autoimmune...
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