Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTPN22 C1858T polymorphism and human brucellosis.

Scandinavian journal of infectious diseases - 1 Jan 2009

Bravo Maria Jose, Colmenero Juan Dios, Queipo-Ortuño Maria Isabel, Morata Pilar, Orozco Gisela, Martin Javier, Alonso Antonio, Caballero Abelardo

Abstract excerpt

The PTPN22 gene encodes for an intracellular lymphoid-specific phosphatase (Lyp) that has a negative regulatory effect on T-cell activation. The minor allele of the single nucleotide polymorphism (SNP) in the PTPN22 gene encoding the Lyp-tyrosine phosphatase has been associated with multiple autoimmune disorders and with susceptibility to M. tuberculosis. It is possible, therefore, that variants of this gene may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brucellosis
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Data Interpretation, Statistical

Share to Gene Frequency

Share to PTPN22 gene

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Identifiers

PMID: 19107641
DOI: 10.1080/00365540802641864

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTPN22 C1858T polymorphism and human brucellosis.PMID 19107641Read ↗

Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance.Semantic proximity Read ↗

Genetic influence of PTPN22 R620W polymorphism in tuberculosis.Semantic proximity Read ↗

PTPN22 1858C>T (R620W) functional polymorphism and human longevity.Semantic proximity Read ↗

Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphism in pulmonary tuberculosis in the Indian population.Semantic proximity Read ↗

R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast IranSemantic proximity Read ↗

Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection.Semantic proximity Read ↗

Role of the PTPN22 C1858T (R263Q) variant in tuberculosis susceptibility: genetic and functional evidence from a South Asian cohort.Semantic proximity Read ↗

The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.Semantic proximity Read ↗

PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility.Semantic proximity Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.