The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease.

doi:10.1111/j.1399-0039.2005.00428.x

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Article

The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease.

Tissue antigens - 1 Oct 2005

Martín M C, Oliver J, Urcelay E, Orozco G, Gómez-Garcia M, López-Nevot M A, Piñero A, Brieva J A, de la Concha E G, Nieto A, Martín J

Abstract excerpt

The aim of this study was to assess the possible association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene 1858C-->T (rs2476601, encoding R620W) polymorphism and inflammatory bowel disease (IBD). Our study population consisted of 1113 IBD [544 ulcerative colitis (UC) and 569 Crohn's disease (CD)] patients and 812 healthy subjects. All the individuals were of Spanish white origin....

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Source

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Identifiers

PMID: 16185327
DOI: 10.1111/j.1399-0039.2005.00428.x

Genes

PTPN22

Variants

rs2476601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease.PMID 16185327Read ↗

C1858T functional variant of PTPN22 gene is not associated with celiac disease genetic predisposition.Semantic proximity Read ↗

A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.Semantic proximity Read ↗

Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.Semantic proximity Read ↗

The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.Semantic proximity Read ↗

Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.Semantic proximity Read ↗

A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.Semantic proximity Read ↗

Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn’s disease and ulcerative colitisSemantic proximity Read ↗

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