Article
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.
Genes and immunity - 1 May 2005
Viken M K, Amundsen S S, Kvien T K, Boberg K M, Gilboe I M, Lilleby V, Sollid L M, Førre O T, Thorsby E, Smerdel A, Lie B A
Abstract excerpt
A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene, encoding a tyrosine phosphatase, has been reported to be associated with type I diabetes and some other autoimmune diseases. To further investigate whether this polymorphism may be a general susceptibility factor for autoimmunity, we performed an association study in five different autoimmune diseases, three previously not tested. We found...
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