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Article

PTPN22 1858T is not a risk factor for North American pemphigus vulgaris.

Experimental dermatology - 1 Jun 2011

Sachdev Amit, Bhanusali Dhaval G, Patterson Kevin C, Zamora Matt B, Ghuman Apram, Gerlach John A, Sinha Animesh A

Abstract excerpt

Alterations in the protein tyrosine phosphatase N22 (PTPN22) gene affect the threshold for lymphocyte activation. The PTPN22 1858T polymorphism leads to uninhibited T-cell receptor cascade propagation. An elevated PTPN22 1858C/T genotype frequency has been correlated with several autoimmune disorders which have T-cell and humoral components. However, a recent Tunisian report demonstrated no association between...

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Source

Identifiers

PMID: 21585555
DOI: 10.1111/j.1600-0625.2011.01272.x

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PTPN22 1858T is not a risk factor for North American pemphigus vulgaris.PMID 21585555Read ↗

C1858T functional variant of PTPN22 gene is not associated with celiac disease genetic predisposition.Semantic proximity Read ↗

Clinical characteristics and PTPN22 1858C/T variant analysis in Jordanian Arab vitiligo patients.Semantic proximity Read ↗

PTPN22 profile indicates a novel risk group in Alopecia areata.Semantic proximity Read ↗

The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata.Semantic proximity Read ↗

PTPN22 620W allele is not associated with aplastic anemia.Semantic proximity Read ↗

Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to Henoch-Schönlein purpura.Semantic proximity Read ↗

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.Semantic proximity Read ↗

No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome.Semantic proximity Read ↗

The PTPN22 1858T variant is not associated with primary biliary cirrhosis.Semantic proximity Read ↗

PTPN22 1858C>T (R620W) functional polymorphism and human longevity.Semantic proximity Read ↗

PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results.Semantic proximity Read ↗

Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis.Semantic proximity Read ↗

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