Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP).

doi:10.1016/0006-291x(91)92027-h

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Article

Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP).

Biochemical and biophysical research communications - 31 Dec 1991

Nara Y, Nabika T, Ikeda K, Sawamura M, Endo J, Yamori Y

Abstract excerpt

We investigated the linkage between high blood pressure and the ACE gene in the F2 generation between SHRSP/Izm and WKY/Izm. The male F2 rats were categorized into 3 genotypes according to a microsatellite polymorphism in the ACE gene. Significantly high blood pressure was observed in the SHRSP homozygotes when it was compared to the blood pressure of the heterozygotes. Further, after 2 or 3 months salt-loading,...

Topics

Animals
Appetite
Blood Pressure
Crosses, Genetic
DNA Fingerprinting
Female
Genetic Carrier Screening
Genetic Linkage
Genotype
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Peptidyl-Dipeptidase A

Polymerase Chain Reaction

Polymorphism, Genetic

Rats

Rats, Inbred SHR

Rats, Inbred WKY

Sodium, Dietary

Source

Open in PubMed

Identifiers

PMID: 1662504
DOI: 10.1016/0006-291x(91)92027-h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1662504-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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