Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.

doi:10.1038/ng0792-267

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Article

Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.

Nature genetics - 1 Jul 1992

Deng Y, Rapp J P

Abstract excerpt

We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci...

Topics

Animals
Base Sequence
Blood Pressure
Crosses, Genetic
Female
Genetic Linkage
Genotype
Guanylate Cyclase
Male
Molecular Sequence Data
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptidyl-Dipeptidase A

Polymerase Chain Reaction

Rats

Rats, Inbred BN

Rats, Inbred Lew

Rats, Inbred SHR

Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 1363813
DOI: 10.1038/ng0792-267

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1363813-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.PMID 1363813Read ↗

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