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Article

Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.

Nature genetics - 1 Jul 1992

Deng Y, Rapp J P

Abstract excerpt

We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci...

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Source

Identifiers

PMID: 1363813
DOI: 10.1038/ng0792-267

Genes

ACE
GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.PMID 1363813Read ↗

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Angiotensin I converting enzyme gene cosegregates with blood pressure and heart weight in F2 progeny derived from spontaneously hypertensive and normotensive Wistar-Kyoto rats.Semantic proximity Read ↗

A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.Semantic proximity Read ↗

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Failure of alleles at the Na+, K(+)-ATPase alpha 1 locus to cosegregate with blood pressure in Dahl rats.Semantic proximity Read ↗

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