Article
Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.
The Journal of clinical investigation - 1 May 1995
Deng A Y, Rapp J P
Abstract excerpt
Alleles of the inducible nitric oxide synthase locus (Nos2) cosegregated highly significantly (P < 0.0001) with blood pressure in an F2 population [F2(S x MNS), n = 171] derived from a cross of inbred Dahl salt-sensitive (S) rats with Milan normotensive rats (MNS). In contrast, alleles at the con...
Topics
- Amino Acid Oxidoreductases
- Animals
- Base Sequence
- Blood Pressure
- Brain
- Chromosome Mapping
- Crosses, Genetic
- DNA Primers
- Enzyme Induction
- Genetic Markers
- Genotype
- Hypertension
- Isoenzymes
- Molecular Sequence Data
- Nitric Oxide Synthase
- Peptidyl-Dipeptidase A
- Polymerase Chain Reaction
- Polymorphism, Genetic