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Article

Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 1994

Hübner N, Kreutz R, Takahashi S, Ganten D, Lindpaintner K

Abstract excerpt

Recently, evidence has been presented for genetic linkage between the angiotensinogen gene and primary hypertension in humans. In the present study we examined whether a similar linkage between blood pressure and the angiotensinogen gene locus can be demonstrated in a widely used animal model of primary hypertension, the stroke-prone spontaneously hypertensive rat (Heidelberg colony, SHRSPHD). In 115 F2 hybrids...

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Identifiers

PMID: 7911449
DOI: 10.1161/01.hyp.23.6.797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus.PMID 7911449Read ↗

Structural alterations of the renin gene in stroke-prone spontaneously hypertensive rats: examination of genotype-phenotype correlations.Semantic proximity Read ↗

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.Semantic proximity Read ↗

Genetics of hypertension: an assessment of progress in the spontaneously hypertensive rat.Semantic proximity Read ↗

Evidence for primary genetic determination of heart rate regulation: chromosomal mapping of a genetic locus in the rat.Semantic proximity Read ↗

Analysis of the role of angiotensinogen in spontaneous hypertension.Semantic proximity Read ↗

Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats. A study on cause and effect.Semantic proximity Read ↗

[Cosegregation studies in spontaneously hypertensive rats].Semantic proximity Read ↗

Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP).Semantic proximity Read ↗

Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.Semantic proximity Read ↗

Cosegregation of spontaneously hypertensive rat renin gene with elevated blood pressure in an F2 generation.Semantic proximity Read ↗

A twofold genetic increase of ACE expression has no effect on the development of spontaneous hypertension.Semantic proximity Read ↗

Dissecting the primary causes of genetic hypertension in rats.Semantic proximity Read ↗

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