Article
Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 1994
Hübner N, Kreutz R, Takahashi S, Ganten D, Lindpaintner K
Abstract excerpt
Recently, evidence has been presented for genetic linkage between the angiotensinogen gene and primary hypertension in humans. In the present study we examined whether a similar linkage between blood pressure and the angiotensinogen gene locus can be demonstrated in a widely used animal model of primary hypertension, the stroke-prone spontaneously hypertensive rat (Heidelberg colony, SHRSPHD). In 115 F2 hybrids...
Topics
- Angiotensinogen
- Animals
- Base Sequence
- Blood Pressure
- Chromosome Mapping
- Genetic Linkage
- Genotype
- Molecular Probes
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction