Article
Cosegregation of the renin gene with an increase in mean arterial blood pressure in the F2 rats of SHR-WKY cross.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Sept 1994
Sun L, McArdle S, Chun M, Wolff D W, Pettinger W A
Abstract excerpt
Using the restriction endonuclease, BgI I, Samani et al. found a restriction fragment length polymorphism (RFLP) for the renin gene in spontaneously hypertensive rats (SHR) and its normotensive control Wistar-Kyoto (WKY) rats. This RFLP was confirmed in our laboratory in SHR and WKY rats using a rat renin cDNA probe. The correlation of blood pressure and the renin RFLP was examined in 106 F2 rats produced from F1...
Topics
- Alleles
- Animals
- Blood Pressure
- Blotting, Southern
- Female
- Genotype
- Homozygote
- Hybridization, Genetic
- Male
- Polymorphism, Restriction Fragment Length
- Rats