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Article

Suppressors of DnaA(ATP) imposed overinitiation in Escherichia coli.

Molecular microbiology - 1 Feb 2011

Charbon Godefroid, Riber Leise, Cohen Malene, Skovgaard Ole, Fujimitsu Kazuyuki, Katayama Tsutomu, Løbner-Olesen Anders

Abstract excerpt

Chromosome replication in Escherichia coli is limited by the supply of DnaA associated with ATP. Cells deficient in RIDA (Regulatory Inactivation of DnaA) due to a deletion of the hda gene accumulate suppressor mutations (hsm) to counteract the overinitiation caused by an elevated DnaA(ATP) level. Eight spontaneous hda suppressor mutations were identified by whole-genome sequencing, and three of these were...

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Source

Identifiers

PMID: 21299647
DOI: 10.1111/j.1365-2958.2010.07493.x

Genes

RIDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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