Modes of overinitiation, dnaA gene expression, and inhibition of cell division in a novel cold-sensitive hda mutant of Escherichia coli.

doi:10.1128/JB.00044-08

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Modes of overinitiation, dnaA gene expression, and inhibition of cell division in a novel cold-sensitive hda mutant of Escherichia coli.

Journal of bacteriology - 1 Aug 2008

Fujimitsu Kazuyuki, Su'etsugu Masayuki, Yamaguchi Yoko, Mazda Kensaku, Fu Nisi, Kawakami Hironori, Katayama Tsutomu

Abstract excerpt

The chromosomal replication cycle is strictly coordinated with cell cycle progression in Escherichia coli. ATP-DnaA initiates replication, leading to loading of the DNA polymerase III holoenzyme. The DNA-loaded form of the beta clamp subunit of the polymerase binds the Hda protein, which promotes ATP-DnaA hydrolysis, yielding inactive ADP-DnaA. This regulation is required to repress overinitiation. In this study,...

Topics

Adenosine Triphosphatases
Bacterial Outer Membrane Proteins
Bacterial Proteins
Carrier Proteins
Cell Division
Cold Temperature
Cytosol
DNA Replication
DNA-Binding Proteins
Deoxyadenine Nucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Deoxycytosine Nucleotides

DnaB Helicases

Escherichia coli

Escherichia coli Proteins

Gene Dosage

Gene Expression Profiling

Hot Temperature

Mutagenesis, Insertional

Source

Open in PubMed Open full text

Identifiers

PMID: 18502852
DOI: 10.1128/JB.00044-08
PMCID: PMC2493284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modes of overinitiation, dnaA gene expression, and inhibition of cell division in a novel cold-sensitive hda mutant of Escherichia coli.PMID 18502852Read ↗

Insufficient levels of the nrdAB-encoded ribonucleotide reductase underlie the severe growth defect of the Δhda E. coli strain.Semantic proximity Read ↗

Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication.Semantic proximity Read ↗

Suppressors of DnaA(ATP) imposed overinitiation in Escherichia coli.Semantic proximity Read ↗

Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein.Semantic proximity Read ↗

Mutant DnaAs of Escherichia coli that are refractory to negative control.Semantic proximity Read ↗

A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli.Semantic proximity Read ↗

Countermeasures to survive excessive chromosome replication in Escherichia coli.Semantic proximity Read ↗

A role for nonessential domain II of initiator protein, DnaA, in replication control.Semantic proximity Read ↗

A nucleotide switch in the Escherichia coli DnaA protein initiates chromosomal replication: evidnece from a mutant DnaA protein defective in regulatory ATP hydrolysis in vitro and in vivo.Semantic proximity Read ↗

The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes.Semantic proximity Read ↗

HdaB: a novel and conserved DnaA-related protein that targets the RIDA process to stimulate replication initiation.Semantic proximity Read ↗

An isolated Hda-clamp complex is functional in the regulatory inactivation of DnaA and DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.