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Article

A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli.

The EMBO journal - 8 Mar 2006

Gon Stéphanie, Camara Johanna E, Klungsøyr Hege K, Crooke Elliott, Skarstad Kirsten, Beckwith Jon

Abstract excerpt

We present evidence for a complex regulatory interplay between the initiation of DNA replication and deoxyribonucleotide synthesis. In Escherichia coli, the ATP-bound DnaA protein initiates chromosomal replication. Upon loading of the beta-clamp subunit (DnaN) of the replicase, DnaA is inactivated as its intrinsic ATPase activity is stimulated by the protein Hda. The beta-subunit acts as a matchmaker between Hda...

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Identifiers

PMID: 16482221
DOI: 10.1038/sj.emboj.7600990
PMCID: PMC1409723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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