Article
A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli.
The EMBO journal - 8 Mar 2006
Gon Stéphanie, Camara Johanna E, Klungsøyr Hege K, Crooke Elliott, Skarstad Kirsten, Beckwith Jon
Abstract excerpt
We present evidence for a complex regulatory interplay between the initiation of DNA replication and deoxyribonucleotide synthesis. In Escherichia coli, the ATP-bound DnaA protein initiates chromosomal replication. Upon loading of the beta-clamp subunit (DnaN) of the replicase, DnaA is inactivated as its intrinsic ATPase activity is stimulated by the protein Hda. The beta-subunit acts as a matchmaker between Hda...
Topics
- Adenosine Diphosphate
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Bacterial Proteins
- Cell Cycle
- Chromosomes, Bacterial
- DNA Polymerase III
- DNA Replication
- DNA, Bacterial
- DNA-Binding Proteins
- Deoxyribonucleotides
- Escherichia coli
- Escherichia coli Proteins