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Article

Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication.

EMBO reports - 1 Aug 2005

Camara Johanna E, Breier Adam M, Brendler Therese, Austin Stuart, Cozzarelli Nicholas R, Crooke Elliott

Abstract excerpt

Initiation of DNA replication from the Escherichia coli chromosomal origin is highly regulated, assuring that replication occurs precisely once per cell cycle. Three mechanisms for regulation of replication initiation have been proposed: titration of free DnaA initiator protein by the datA locus, sequestration of newly replicated origins by SeqA protein and regulatory inactivation of DnaA (RIDA), in which active...

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Identifiers

PMID: 16041320
DOI: 10.1038/sj.embor.7400467
PMCID: PMC1369143

Genes

RIDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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