Article
Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways.
Current biology : CB - 4 Apr 2006
Ibarra Neysi, Blagg Simone L, Vazquez Francisca, Insall Robert H
Abstract excerpt
SCAR--also known as WAVE--is a key regulator of actin dynamics. Activation of SCAR enhances the nucleation of new actin filaments through the Arp2/3 complex, causing a localized increase in the rate of actin polymerization . In vivo, SCAR is held in a large regulatory complex, which includes PIR121 and Nap1 proteins, whose precise role is unclear. It was initially thought to hold SCAR inactive until needed , but...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.