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Article

WASP family proteins and formins compete in pseudopod- and bleb-based migration.

The Journal of cell biology - 5 Feb 2018

Davidson Andrew J, Amato Clelia, Thomason Peter A, Insall Robert H

Abstract excerpt

Actin pseudopods induced by SCAR/WAVE drive normal migration and chemotaxis in eukaryotic cells. Cells can also migrate using blebs, in which the edge is driven forward by hydrostatic pressure instead of actin. In Dictyostelium discoideum, loss of SCAR is compensated by WASP moving to the leading edge to generate morphologically normal pseudopods. Here we use an inducible double knockout to show that cells...

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Identifiers

PMID: 29191847
DOI: 10.1083/jcb.201705160
PMCID: PMC5800805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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