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Article

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime.

PLoS biology - 1 Aug 2020

Singh Shashi Prakash, Thomason Peter A, Lilla Sergio, Schaks Matthias, Tang Qing, Goode Bruce L, Machesky Laura M, Rottner Klemens, Insall Robert H

Abstract excerpt

The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE's proline-rich domain is polyphosphorylated after the complex is activated. Blocking Scar/WAVE activation stops phosphorylation in both Dictyostelium and mammalian cells, implying that phosphorylation modulates pseudopods after they have been formed, rather than controlling whether they are...

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Identifiers

PMID: 32745097
DOI: 10.1371/journal.pbio.3000774
PMCID: PMC7425996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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