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Article

Extracellular Signalling Modulates Scar/WAVE Complex Activity through Abi Phosphorylation.

Cells - 10 Dec 2021

Singh Shashi Prakash, Thomason Peter A, Insall Robert H

Abstract excerpt

The lamellipodia and pseudopodia of migrating cells are produced and maintained by the Scar/WAVE complex. Thus, actin-based cell migration is largely controlled through regulation of Scar/WAVE. Here, we report that the Abi subunit-but not Scar-is phosphorylated in response to extracellular signalling in Dictyostelium cells. Like Scar, Abi is phosphorylated after the complex has been activated, implying that Abi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34943993
DOI: 10.3390/cells10123485
PMCID: PMC8700165

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