Chronic ethanol treatment alters brain levels of gamma-aminobutyric acidA receptor subunit mRNAs: relationship to genetic differences in ethanol withdrawal seizure severity.

Abstract excerpt

Chronic ethanol treatment is known to alter the function of the gamma-aminobutyric acidA (GABAA) benzodiazepine receptor complex. To determine if genetic differences in development of ethanol dependence are related to expression of GABAA receptor subunits, we measured whole brain levels of mRNA f...

Topics

• Animals
• Brain
• Ethanol
• Genetic Predisposition to Disease
• Male
• Mice
• RNA, Messenger
• Receptors, GABA-A
• Seizures
• Substance Withdrawal Syndrome
• Time Factors