Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.

doi:10.1111/j.1471-4159.1991.tb06428.x

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Article

Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.

Journal of neurochemistry - 1 Dec 1991

Buck K J, McQuilkin S J, Harris R A

Abstract excerpt

To determine whether genetic differences in development of ethanol dependence are related to changes in gamma-aminobutyric acidA (GABAA) receptor function, we measured 36Cl- uptake by brain cortical membrane vesicles from withdrawal seizure prone and withdrawal seizure resistant (WSP/WSR) mice treated chronically with ethanol. Muscimol-stimulated chloride flux was not different between WSP and WSR mice before or...

Topics

Animals
Benzodiazepines
Carbolines
Chloride Channels
Chlorides
Convulsants
Ethanol
Flunitrazepam
Genetic Predisposition to Disease
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred Strains

Muscimol

Receptors, GABA-A

Seizures

Substance Withdrawal Syndrome

Source

Open in PubMed

Identifiers

PMID: 1658234
DOI: 10.1111/j.1471-4159.1991.tb06428.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1658234-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.PMID 1658234Read ↗

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