Article
Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice.
Alcoholism, clinical and experimental research - 1 Feb 1998
Homanics G E, Le N Q, Kist F, Mihalek R, Hart A R, Quinlan J J
Abstract excerpt
We have been using a genetic strategy to define the contribution of specific candidate genes, such as those encoding subunits of the gamma-aminobutyric acid type A receptor, to various ethanol sensitive responses. We have used the gene knockout approach in mouse embryonic stem cells to create mic...
Topics
- Alcohol Withdrawal Delirium
- Alcoholism
- Alleles
- Animals
- Drug Tolerance
- Ethanol
- Genotype
- Male
- Metabolic Clearance Rate
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Knockout
- Models, Genetic
- Point Mutation
- RNA, Messenger
- Receptors, GABA-A