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Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice.

Alcoholism, clinical and experimental research - 1 Feb 1998

Homanics G E, Le N Q, Kist F, Mihalek R, Hart A R, Quinlan J J

Abstract excerpt

We have been using a genetic strategy to define the contribution of specific candidate genes, such as those encoding subunits of the gamma-aminobutyric acid type A receptor, to various ethanol sensitive responses. We have used the gene knockout approach in mouse embryonic stem cells to create mice in which the gene encoding the alpha6 subunit of the gamma-aminobutyric acid type A receptor is rendered...

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PMID: 9514316

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