gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions.

doi:10.1016/j.bcp.2004.07.023

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Article

gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions.

Biochemical pharmacology - 15 Oct 2004

Boehm Stephen L, Ponomarev Igor, Jennings Andrew W, Whiting Paul J, Rosahl Thomas W, Garrett Elisabeth M, Blednov Yuri A, Harris R Adron

Abstract excerpt

gamma-Aminobutyric acid A (GABA(A)) receptors are believed to mediate a number of alcohol's behavioral actions. Because the subunit composition of GABA(A) receptors determines receptor pharmacology, behavioral sensitivity to alcohol (ethanol) may depend on which subunits are present (or absent). A number of knock-out and/or transgenic mouse models have been developed (alpha1, alpha2, alpha5, alpha6, beta2, beta3,...

Topics

Animals
Ethanol
Humans
Mice
Mice, Knockout
Motor Activity
Mutation
Protein Subunits
Quantitative Trait Loci
Receptors, GABA-A
Reflex
gamma-Aminobutyric Acid

Source

Open in PubMed

Identifiers

PMID: 15451402
DOI: 10.1016/j.bcp.2004.07.023

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