Article
Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.
Neuropharmacology - 1 Feb 1999
Homanics G E, Harrison N L, Quinlan J J, Krasowski M D, Rick C E, de Blas A L, Mehta A K, Kist F, Mihalek R M, Aul J J, Firestone L L
Abstract excerpt
The gamma subunit of the gamma-aminobutyric acid type A receptor (GABA(A)-R) is essential for bestowing both normal single channel conductance and sensitivity to benzodiazepines on native GABA(A)-Rs. The long splice variant of the gamma2 subunit (gamma2L) has been postulated to be essential in mediating the modulatory actions of ethanol at the GABA(A)-R. In order to evaluate this hypothesis, gene targeting was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.