Human GABAA receptor alpha 1 and alpha 3 subunits genes and alcoholism.

Article

Human GABAA receptor alpha 1 and alpha 3 subunits genes and alcoholism.

Alcoholism, clinical and experimental research - 1 May 1997

Parsian A, Cloninger C R

Abstract excerpt

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. GABA effects are largely mediated by binding to the postsynaptic GABAA receptor, causing the opening of an integral chloride-ion channel. The GABAA antagonists picrotoxin and bicuculline reduce some ethanol-indu...

Topics

Adult
Alcoholism
Alleles
Female
Gene Frequency
Haplotypes
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, GABA-A
Risk

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