Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.

doi:10.1001/archpsyc.63.9.957

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Article

Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.

Archives of general psychiatry - 1 Sept 2006

Krystal John H, Staley Julie, Mason Graeme, Petrakis Ismene L, Kaufman Joan, Harris R Adron, Gelernter Joel, Lappalainen Jaakko

Abstract excerpt

CONTEXT: Alcohol facilitates gamma-aminobutyric acid (GABA) function, and GABA type A (GABA(A)) receptor-facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular neuroscience, genetics, and neuroimaging provide new insights into the role of brain GABA systems in short- and long-term alcohol effects. OBJECTIVE: To review the role of brain GABA systems in alcohol response, alcohol dependence,...

Topics

Alcoholism
Benzodiazepines
Brain
Cerebral Cortex
Gene Expression
Genetic Predisposition to Disease
Humans
Receptors, GABA-A
Risk Factors
Substance Withdrawal Syndrome
gamma-Aminobutyric Acid

Source

Open in PubMed

Identifiers

PMID: 16952998
DOI: 10.1001/archpsyc.63.9.957

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