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Article

Smad3 knock-out mice as a useful model to study intestinal fibrogenesis.

World journal of gastroenterology - 28 Feb 2006

Zanninelli Giuliana, Vetuschi Antonella, Sferra Roberta, D'Angelo Angela, Fratticci Amato, Continenza Maria Adelaide, Chiaramonte Maria, Gaudio Eugenio, Caprilli Renzo, Latella Giovanni

Abstract excerpt

AIM: To evaluate the possible differences in morphology and immunohistochemical expression of CD3, transforming growth factor beta1 (TGF-beta1), Smad7, alpha-smooth muscle actin (alpha-Sma), and collagen types I-VII of small and large intestine in Smad3 null and wild-type mice. METHODS: Ten null and ten wild-type adult mice were sacrificed at 4 mo of age and the organs (esophagus, small and large bowel, ureters)...

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Source

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Identifiers

PMID: 16534873
DOI: 10.3748/wjg.v12.i8.1211
PMCID: PMC4124431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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