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Article

Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.

Kidney international - 1 Aug 2004

Inazaki Kumi, Kanamaru Yutaka, Kojima Yuko, Sueyoshi Noriyoshi, Okumura Ko, Kaneko Kazunari, Yamashiro Yuichiro, Ogawa Hideoki, Nakao Atsuhito

Abstract excerpt

BACKGROUND: Transforming growth factor-beta (TGF-beta) has been implicated in the development of renal fibrosis induced by unilateral ureteral obstruction (UUO). However, there is little information on signaling pathways mediating TGF-beta activity involved in molecular and cellular events leading to renal fibrosis induced by UUO. In this study, we sought to determine whether Smad3, a major signaling component of...

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Identifiers

PMID: 15253712
DOI: 10.1111/j.1523-1755.2004.00779.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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