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Article

Smad3 gene C-terminal phosphorylation site mutation aggravates CCl4 -induced inflammation in mice.

Journal of cellular and molecular medicine - 1 Jun 2020

Ding Hanyan, Fang Meng, Gong Yongfang, Li Dong, Zhang Chong, Wen Guanghua, Wu Chao, Yang Jingjing, Yang Yan

Abstract excerpt

The expression of C-terminal phosphorylated Smad3 (pSmad3C) is down-regulated with the progression of liver disease. Thus, we hypothesized that pSmad3C expression may be negatively related to liver disease. To develop novel therapeutic strategies, a suitable animal model is required that will allow researchers to study the effect of Smad3 domain-specific phosphorylation on liver disease progression. The current...

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Identifiers

PMID: 32406200
DOI: 10.1111/jcmm.15385
PMCID: PMC7299733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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