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Article

Severe Intestinal Inflammation in the Small Intestine of Mice Induced by Controllable Deletion of Claudin-7.

Digestive diseases and sciences - 1 May 2018

Li Wen-Jing, Xu Chang, Wang Kun, Li Teng-Yan, Wang Xiao-Nan, Yang Hui, Xing Tiaosi, Li Wen-Xia, Chen Yan-Hua, Gao Hong, Ding Lei

Abstract excerpt

BACKGROUND: As a potential tumor suppressor gene, Claudin-7 (Cldn7), which is a component of tight junctions, may play an important role in colorectal cancer occurrence and development. AIMS: To generate a knockout mouse model of inducible conditional Cldn7 in the intestine and analyze the phenotype of the mice after induction with tamoxifen. METHODS: We constructed Cldn7-flox transgenic mice and crossed them...

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Identifiers

PMID: 29488037
DOI: 10.1007/s10620-018-4973-z
PMCID: PMC5897149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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