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Article

Smad3 mutant mice develop metastatic colorectal cancer.

Cell - 18 Sept 1998

Zhu Y, Richardson J A, Parada L F, Graff J M

Abstract excerpt

TGFbeta-related growth factors have been implicated in a variety of developmental and physiological processes in organisms ranging from nematodes to mammals. TGFbeta transduces its signal to the interior of the cell via Smad2, Smad3, and Smad4. We report the cloning and targeted disruption of the mouse Smad3 gene. Smad3 mutant mice are viable and fertile. Between 4 and 6 months of age, the Smad3 mutant mice...

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Source

Identifiers

PMID: 9753318
DOI: 10.1016/s0092-8674(00)81730-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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