Smad3 mutant mice develop metastatic colorectal cancer.

doi:10.1016/s0092-8674(00)81730-4

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Article

Smad3 mutant mice develop metastatic colorectal cancer.

Cell - 18 Sept 1998

Zhu Y, Richardson J A, Parada L F, Graff J M

Abstract excerpt

TGFbeta-related growth factors have been implicated in a variety of developmental and physiological processes in organisms ranging from nematodes to mammals. TGFbeta transduces its signal to the interior of the cell via Smad2, Smad3, and Smad4. We report the cloning and targeted disruption of the...

Topics

Adenocarcinoma
Adenomatous Polyposis Coli Protein
Alleles
Animals
Cell Division
Cloning, Molecular
Colorectal Neoplasms
Cytoskeletal Proteins
DNA-Binding Proteins
Female
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Recessive

Genes, Reporter

Heterozygote

Hybridization, Genetic

Lac Operon

Lymph Nodes

Source

Open in PubMed

Identifiers

PMID: 9753318
DOI: 10.1016/s0092-8674(00)81730-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9753318-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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