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Validation studies for germ-free Smad3 -/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD

29 May 2019

Abstract excerpt

While the association between microbiomes and inflammatory bowel disease (IBD) is well known, establishing causal relationships between the two is difficult in humans. Germ-free (GF) mice genetically susceptible to IBD can address this question. Smad3-/- mice with defective transforming growth factor ß signaling are a model of IBD and colon cancer. They develop IBD upon colonization with Helicobacter under...

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PMID: 31138018
DOI: 10.1080/19490976.2019.1611151

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