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Article

Smad7-modified alleles by various gene-targeting strategies.

Journal of biochemistry - 1 May 2013

Beppu Hideyuki

Abstract excerpt

Signalling of the transforming growth factor-β (TGF-β) family is tightly regulated by various mechanisms including negative feedback by Inhibitory Sma- and Mad-related proteins (Smads) (I-Smads: Smad6 and Smad7). Smad6 preferentially inhibits bone morphogenetic protein (BMP) signalling, whereas Smad7 suppresses both TGF-β and BMP signalling. To elucidate the roles of Smad7 in murine development and in TGF-β...

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Identifiers

PMID: 23509008
DOI: 10.1093/jb/mvt020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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