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Article

Smad7 in intestinal CD4 <sup>+</sup> T cells determines autoimmunity in a spontaneous model of multiple sclerosis

3 Dec 2019

Abstract excerpt

Significance Mechanisms leading to initiation of the autoimmune disorder multiple sclerosis (MS) are still elusive. Environmental triggers acting at barrier organs such as the intestine could contribute to local activation of autoreactive lymphocytes and consecutive migration to the CNS. Here, we demonstrate that overexpression of the TGF-beta inhibitor Smad7 in intestinal CD4 + T cells of mice lowered the...

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PMID: 31796589
DOI: 10.1073/pnas.1905955116

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