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Article

Role of Smad7 in inflammatory bowel diseases

1 Jan 2012

Abstract excerpt

Crohn's disease and ulcerative colitis, the major forms of inflammatory bowel diseases (IBD) in man, are complex diseases in which genetic and environmental factors interact to promote an excessive mucosal immune response directed against normal components of the bacterial microflora. There is also evidence that the pathologic process is due to defects in counter-regulatory mechanisms, such as those involving the...

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PMID: 23155305
DOI: 10.3748/wjg.v18.i40.5664

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