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Article

Gastro-intestinal tumorigenesis in Smad4 mutant mice.

Cytokine & growth factor reviews - 1 Jan 2000

Taketo M M, Takaku K

Abstract excerpt

The SMAD4 gene plays a key role in the TGF-beta signaling pathway. We inactivated its mouse homolog Smad4. The homozygous mutants were embryonically lethal, whereas the heterozygotes were viable and fertile. Although young heterozygotes appeared normal, old mice developed gastric and duodenal polyps similar to human juvenile polyps characterized by abundant stroma and eosinophilic infiltrations. These data are...

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Source

Identifiers

PMID: 10708962
DOI: 10.1016/s1359-6101(99)00038-6

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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