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Article

Generation and Characterization of Smad7 Conditional Knockout Mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Pan Yi, Chen Yan

Abstract excerpt

Smad7 is an important negative modulator that regulates the duration and strength of TGF-β signaling. Dysregulation of Smad7 is associated with the pathogenesis of many human diseases. Various mouse models are developed to facilitate addressing the physiological functions of Smad7. We have recently demonstrated that loss of Smad7 function by deletion in its MH2 domain leads to multiple cardiac defects and...

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PMID: 26520128
DOI: 10.1007/978-1-4939-2966-5_14

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