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Article

Smad3-null mice lack interstitial cells of Cajal in the colonic wall.

European journal of clinical investigation - 1 Jan 2006

Vetuschi A, Sferra R, Latella G, D'Angelo A, Catitti V, Zanninelli G, Continenza M A, Gaudio E

Abstract excerpt

BACKGROUND: Transforming growth factor-beta (TGF-beta)/Smad's signalling pathway plays a pivotal role in organogenesis, oncogenesis, inflammation, repair and fibrosis. The aim of this study was to evaluate the morphology of muscle layers and the density and distribution of interstitial cells of Cajal (ICC) in the colon of Smad3 knockout mice. MATERIALS AND METHODS: Eighteen Smad3 wild-type mice and 12 null mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16403009
DOI: 10.1111/j.1365-2362.2006.01593.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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